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What Is Sermorelin? (GRF 1-29)

Sermorelin stimulates growth hormone production and results in increased muscle mass, lowers body fat, improves recovery, enhances sleep, improves flexibility and joint health, and optimizes overall health and wellness.

It is a synthetically made version of growth hormone releasing hormone (GHRH). GHRH is normally made in the body is responsible for stimulating natural growth hormone production. I is typically categorized as a growth hormone secretagogue, a compound which stimulates increased secretion of growth hormone from the pituitary gland.

Sermorelin, like the body’s natural GHRH, works primarily by binding to the GHRH receptor in the anterior part of the pituitary gland. There, it stimulates additional release of GH, which in turn increases the production of endogenous IGF-1. IGF-1 is the active hormone that causes all the positive outcomes. Sermorelin acts in an identical manner to GHRH thus causing release of GH. One of the benefits of using Sermorelin vs IGF-1 is it works by a negative feedback system, so when too much is noted to be in the body, it prevents unhealthy levels of GH. It also mirrors the natural fluctuations of GH concentrations in the body which causes less side effects.

In addition, its natural action mechanism allows for the preservation of the hypothalamic-pituitary-somatotropic axis and prevents the shutdown of hormone production that typically accompanies direct replacement with hGH. Finally, Sermorelin has also been shown to improve sleep quality, enhancing the duration of restorative slow wave sleep and amplifying sleep-related secretion of growth hormone while reducing production of cortisol.

Difference between Sermorelin and Modified GRF 1-29

Sermorelin is often confused with Modified GRF 1-29. They are both similar but these two peptides do have an important difference. These two peptides have a molecular structure comprised of 29 amino acids and possess comparable mechanisms of action (mimicking GHRH to stimulate endogenous GH production).

On the other hand, Modified GRF 1-29 has been altered with changes to four specific amino acids in its chemical structure. These changes are intended to increase the peptide’s stability during storage, transportation, and administration while enhancing its affinity for the GHRH receptor.

What are the Benefits of Sermorelin?

  • naturally improves growth hormone production
  • increased muscle
  • increased lean body mass
  • decreased body fat
  • enhanced recovery from injuries and training sessions
  • better sleep; deeper, more restful sleep
  • improved flexibility and joint health
  • enhanced overall health and wellness
  • increased levels of GH stimulate greater production of Insulin-like Growth Factor 1 (IGF-1) in the body, further driving improvements in lean body composition with accelerated growth of muscle tissue and reduced body fat

Lower than optimal levels of growth hormone in the body can significantly affect an individual’s athletic performance, functional capacity, and overall quality of life. Growth hormone is a crucial component in numerous physiological processes: increased strength, energy, flexibility, vitality, and overall well-being. Suboptimal levels of growth hormone levels is often associated with loss of muscle mass and strength, weaker bones, reduced exercise capacity, increased body fat, decreased stamina, poor recovery, and unrestorative sleep.

Combinations of Peptides:

Many peptides work well alone, but when they are combined with another peptide they are considered to have a synergistic effect, meaning the effects of both peptides are henced but combining them then using them alone. To enhanced GH production, peptides such as GHRP-2, GHRP-6, or Ipamorelin in combination with Sermorelin can result in a powerful synergistic effect.

These peptides’ complementary mechanisms of action can stimulate even greater secretion of GH, resulting in augmented IGF-1 production, improved muscle tissue growth and repair, accelerated wound healing and recovery, enhanced fat metabolism (fat loss), and more powerful anti-aging effects.

Are there Side Effects to Sermorelin Treatments?

de effects of Sermorelin are generally mild and may include:

  • flushing
  • dizziness
  • headache
  • mild pain if any at injection site immediately after administration
  • sleepiness (hence being given at night)
  • interaction with glucocorticoid (steroids)

In most cases, any side effects tend to lessen with continued use.


Sermorelin dosages commonly range from 200mcg (0.2mg) to 1000mcg (1mg)  given 1 to 3 times daily. The peptide is commonly administered once daily before bed or split into 2 – 3 smaller doses spread throughout the day. Both approaches to administration can be effective and have been shown to have a positive results in clinical studies.

Although Sermorelin has a relatively short half-life of 10 – 20 minutes, the peptide stimulate the release of GH for 2 hours after administration. As a result, protocols delivering 3 daily doses of as little as 100 mcg (0.1mg) per administration have been shown to cause a significant increase in GH and IGF-1 secretion. Protocol such as this one will commonly result in a more consistent GH level on a daily basis.

Once daily protocols with administration before bed are very effective and better for ease of use and patient compliance. Clinical studies have shown a once daily injection before bed to produce a substantial increase in 12 hour nocturnal GH production as well as an overall increase in GH and IGF-1 levels. A once-daily protocol, recommended individual dosages are commonly 10mcg (0.1mg) per kilogram (2.2 pounds) of body weight. For example, a 200 lbs man would need approximately 900 mcg (0.9mg) once daily. Most doses of 10 mcg/kg are very effective with a maximum of 20 mcg/kg per day. Higher doses have not shown to be effective.

Schedule Your Appointment Today!

Interested in learning more about Sermorelin Treatment? Call (813) 284-0954 to schedule your appointment with PRAMAH today! Our practice serves Tampa, FL and all nearby areas.

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