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ING 18989 05129




GHK-Cu is a human peptide(glycyl-l-histidyl-l-lysine) that has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts.

The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small, naturally occurring tri-peptide present in human plasma that also can be released from tissues in case of an injury. Since its discovery in 1973, GHK-Cu established itself as a powerful protective and regenerative ingredient, which is currently widely used in skin and hair products

GHK-Cu demonstrated improve tissue repair for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK -Cu has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system.

Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.


  • Tighten loose skin and reverse thinning of aged skin
  • Repair protective skin barrier proteins
  • promote wound healing
  • Improve skin firmness, elasticity, and clarity
  • Reduce fine lines, depth of wrinkles, and improve structure of aged skin
  • Smooth rough skin
  • Reduce photodamage, mottled hyperpigmentation, skin spots and lesions
  • Improve overall skin appearance
  • Stimulate wound healing
  • Protect skin cells from UV radiation
  • Reduce inflammation and free radical damage
  • Increase hair growth and thickness, enlarge hair follicle size
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GHK-Cu works primarily because of its ability to bind copper(II) ions. It was proposed that GHK-Cu small molecular size allows it to bind copper. In addition, researchers found genome-wide effects of GHK-Cu and establish that GHK-Cu is able to up- and down-regulate a significant number of human genes.

The biological effects of GHK-Cu such had wound healing and skin repair are well known and and its effects on gene expression continue to be studied.

For skin, GHK-Cu activates collagen to build up tissue, increase certain enzymes that replenish the skin by removing old cells and increase the matrix of ski to give it a thicker, younger, youthful appearance. Many professional grade topical creams now incorporate GHK-Cu in their ingredients.

GHK-Cu sped up wound healing and contraction and formation of granular tissue, as well as increasing activity of antioxidant enzymes and stimulating blood vessel growth. Dressing soaked (impregnated) with GHK-Cu increased wound healing 10 fold.

Nerve growth with GHK -Cu appears to help restore the skin’s innervation through increased production of neurotrophic factors - especially after an injury when the scar area is devoid of feeling.

GHK appears to support remodeling and restructuring of connective tissue, modulating expression of numerous genes, including up-regulation of genes of the TGF-β pathway. This pathway is necessary for of lung tissue in patients with COPD.

GHK -Cu has potent anti-pain, anti-anxiety (anxiolytic) and anti-aggression actions. Research shows topical applications may help with pain both from a sensory perspective and also an anti-inflammatory sense.


GHK-Cu is supplied as an injectable, creams, and foams.

GHK-Cu injectable is supplied in 60 mg per vial. General dosing is to inject 20 units (0.2mL) subcutaneously daily.

GHK-Cu cream for skin is supplied in 2, 5, or 10 gm per gram

GHK-Cu foam for hair is supplied in ma 5 mg per gram

GHK-Cu is also combined in a cream, gel or foam and is applied 1-2 times daily.

A few examples of combination medication:

  • BPC - 157 / AOD9604 / GHK-Cu 30 gram cream  2mg / 1mg / 2 mg/mL for skin/weight loss/pain
  • BPC-157/ GHK-Cu  30 gram gel - 500 mcg/2 mg  per gram for pain
  • DMAE / Estriol / GHK-CU / hyaluronic acid biopeptide 30 gram cream - 3% / 0.3% / 0.2% / 0.5% for skin
  • DMAE / Estriol / GHK-CU / hyaluronic acid biopeptide 30 gram cream - 3% / 0.3% / 0.2% / 1.5% for skin
  • DMAE / GHK-CU / hyaluronic acid biopeptide 30 gram  - 3% / 0.2% / 1.5% for skin
  • GHK-Cu / Argireline / Leuphasyl Serum or cream  0.2% / 3% / 3% for hair
  • Minoxidil / melatonin / GHK-Cu / tretinoin / caffeine scalp foam


GHK-Cu has little to no side effects. Most important conditions that accumulate copper should not use this product or must be used under the supervision of a physician.

Most common side effect is:

  • injection site reactions (such as pain, swelling, or redness)
  • skin irritation

GHK-Cu can be used with BPC 157 and/ or AOD 9604

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