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MOTS-C
ENERGY / MUSCLE BUILDING PEPTIDE
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WHAT IS MOTS-C
MOTS-C (mitochondrial open-reading-frame of the twelve S rRNA-C) is a peptide made of up 16 amino acids that helps promote and increase metabolism. It can supercharge metabolism and increase the ability to exercise, build muscle and lose weight.
In general, the peptide is located in many different organs such as the liver, brain, and muscle tissues.
Mitochondria themselves, have their own DNA and within the “mitochondrial DNA” (mtDNA) are short open reading frames (sORFs) that can be used to encode and produce peptides.
MOTS-C is a peptide that helps regulate mitochondrial energy to optimize your metabolic balance. This is an important peptide for continuing to build muscle and also reversing or lowering down the aging process.
WHAT ARE THE BENEFITS OF MOTS-C
- weight loss by promoting fatty acid metabolism in the liver
- muscle gain
- osteoporosis prevention by promoting osteoblast activity
- strengthened immunity
- improves endurance
- increased energy by upregulating mitochondria
- promotes metabolic flexibility and homeostasis
- protects against age and diet dependent insulin resistance and obesity
- promotes resistance to metabolic stress
- improves glucose regulation

HOW DOES MOTS-C WORK
MOTS-C helps regulate metabolic functions in the body, including turning glucose into usable energy. MOTS-C targets muscle tissue primarily.
When taken, MOTS-C mimics exercise on the body by increasing insulin sensitivity and increases glucose uptake in myocytes (muscle cells). This process occurs by the AMPK pathway. It is a mimic because traditional exercise increases muscle glucose uptake without stimulating insulin.
AMPK (AMP‐activated protein kinase), was found to be the master switch for metabolism and the central regulator of both glucose and lipid (fat) metabolism. Since the same process has been a target for therapeutic intervention against metabolic conditions such as type‐2 diabetes.
MOTS-c treatment leads to a decrease in the systemic and tissue specific levels of myostatin, which may block the weakening of muscle strength.
This potential double side effect of MOTS-c in skeletal muscle and WAT could be an important target in aging-related diseases. The enhancement of energy expenditure via increasing muscle mass and browning of WAT by MOTS-c may be essential in the protection against common diseases in elderly.
WHAT IS THE DOSAGE OF MOTS-C
MOTS-C is supplied in a 10 mm per ml in a 10 ml vial
Standard dosage is to inject 10 mg subcutaneous once a week. This can be repeated in 6 months and or once every year.
Length of treatment depends on many factors and is typically discuss with your medical provider.
WHAT ARE THE SIDE EFFECTS OF MOTS-C
MORS-C has no reported side effects.
Common side effects of MOTS-C include:
- injection site reactions (such as pain, swelling, or redness)