Chromium: Chromium is an essential nutrient involved in the regulation of carbohydrate and lipid metabolism. Normal dietary intake of chromium in humans and farm animals is often suboptimal. In addition to its effects on glucose, insulin, and lipid metabolism, chromium has been reported to increase lean body mass and decrease percentage body fat, which may lead to weight loss in humans.

Naltrexone is an opiate receptor agonist. It works by reducing the appeal of food. In 2014, the FDA approved the combination of Naltrexone and Bupropion also known as Contrave for the treatment of obesity and long-term weight loss.

Methylcobalamine is the most natural and potent form of vitamin B12 and is water soluble. It is required for proper functioning of red blood cells. It promote optimal oxygen carrying in the blood and therefore promotes lasting energy.

Inositol: is a small molecule with structural similarity to glucose. It is a vitamin-like compound (pseudovitamin) that is sometimes said to belong to the class of B complex vitamins and it is involved in cellular signalling and as a component of cell membranes.

Choline: is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism and prevents excessive fat build up in the liver

Yohimbe: is a dietary supplement is derived from the bark of an evergreen tree found in western and central Africa called the Pausinystalia johimbe. Some studies have found that taking yohimbine led to greater weight loss and decreases in body fat when combined with other weight loss medication.

The best time to take Yohimbe is as a pre–workout supplement, it's best to consume Yohimbe between 15 and 30 minutes prior to exercising. Yohimbe also works best when consumed on an empty stomach, as food intake will trigger a spike in insulin. This, in turn, can blunt the effects of yohimbine.