NO TWO PEOPLE ARE ALIKE, NEITHER ARE THEIR WEIGHT LOSS SOLUTIONS
You medical provider will discuss many options with you and create a plan to help you meet your weight loss goals.
Tesofensine
GAME CHANING WEIGHT LOSS PEPTIDE
WHAT IS TESOFENSINE
Tesofensine was originally investigated for the treatment of Alzheimer's disease and Parkinson's disease and was subsequently dropped from development for these applications after early trial results showed limited efficacy for treatment of these diseases.
However, weight loss was consistently reported as an adverse event in the original studies, especially in overweight and / or obese patients.
WHAT ARE THE BENEFITS OF TESOFENSINE
Clinical trial data suggests it may potentially achieve more significant reductions in weight than that seen with currently approved weight loss agents.
Over a 6-month period, Tesofensine has been shown to cause a significant reduction in weight.
Benefits:
- decreased appetite
- early satiety (feeling fuller sooner after a meal)
- increase basal metabolic rate by 6%
- Decreased abdominal fat
- reduced cravings for sweet, fatty, or salty foods
- neuroprotective - beneficial effects on cognition, particularly in learning and memory
- reduced feelings of depression
- improved self-esteem
- improved insulin sensitivity
HOW DOES TESOFENSINE WORK
Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed to treat neurological disorders such as Parkinson’s disease (PD) and Alzheimer’s disease.
Tesofensine works at the level of the brain by suppressing appetite and increasing your basal metabolic rate. It also increase fat oxidation to aid in reducing abdominal fat.
Tesofensine also targets the pleasure center of the brain that affects mood and food consumption.
Studies show that patients had an overall 5-10% reduction in baseline body weight and a reduction in BMI. Waist and hip circumference, body fat, and visceral body fat were also reduced in comparison to those receiving the placebo.
WHAT IS THE DOSAGE OF TESOFENSINE
Tesofensine is supplied in 250 mcg, 500 mcg and 1000 mcg capsules.
Suggested dosing is 1 capsule daily.
HOW MUCH WEIGHT WILL I LOSE ON TESOFENSINE
The amount of weight loss from one person to another varies because of genetics, kind of diet, amount of exercise and age.
At the end of the 24-week treatment period, tesofensine demonstrated:
- a reduction of 4.5% body weight with 0.25mg daily dose
- 9.2 % reduction of body weight with 0.5mg daily dose
- 10.6% reduction in body weight with a 1 mg dose.
They also demonstrated patients continuing with 0.5mg tesofensine achieved a total mean weight loss of 13–14kg at 24 weeks.
WHAT ARE THE SIDE EFFECTS OF TESOFENSINE
The initial positive findings suggest that tesofensine may be a well-tolerated long-term treatment for obesity, with minimal cardiovascular effects.
Some have reported side effects of tesofensine to be similar to other currently approved diet pills and weight loss medications.
In recent trials, side effects such as dry mouth, insomnia, tachycardia, constipation, nausea, diarrhea, high blood pressure and increases in heart rate were recorded.
